Polarization State Specific Synthetic Promoters for Control of Macrophage Cell Therapies

Iterative Engineering of Polarization-State Responsive Synthetic Promoters for Autonomous Control of Macrophage Polarization Logic

A Platform for Designing Neuron, Astrocyte and Hepatocyte Specific Promoters for Gene Therapy

Engineered Small Molecule Binding Domains for Pharmacologically Responsive Degradation and Proximity Based Therapeutics

Engineered IMiD Regulated Synthetic Transcriptional Switch for Controlled and Dose-Responsive Expression of Therapeutic Payload within FDA-Approved Drug Doses

Small-molecule Regulated Safety Switch for Improved Safety of CAR Cell Therapies in the Brain

Genome-Orthogonal Gene Circuitry: Improved Synthetic Enhancer-Transcription Factor Systems with Minimal Off-Target Effects

Smart Sensor Promoters Drive State-specific Gene Circuits to Convert Immunosuppressive Macrophages into an Anti-tumor Phenotype

Dynamic Injury Response through Engineered Cellular Targeting (DIRECT) - In collaboration with DARPA