Many promising cell and gene therapy programs are limited not by their biological target, but by unpredictable gene expression, safety risks, and regulatory uncertainty. GeneFab’s Synthetic Biology Foundry was built to solve these challenges by engineering precise, reliable, and clinically relevant control of gene expression.

We partner with therapeutic developers to reduce uncertainty, mitigate toxicity, and unlock new therapeutic possibilities—by engineering the regulatory biology at the heart of their platform.

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High‑Performance Regulatory Technologies Designed for Real‑World Use
GeneFab designs, builds, and validates synthetic regulatory elements that perform reliably in complex therapeutic applications —not just in proof‑of‑concept studies.

Core Capabilities

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• Synthetic promoters for targeted cell-type and cell‑state specific gene expression

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• Drug‑responsive switches using FDA‑approved small molecules

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• Complex genetic circuit design and optimization 

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These systems enable therapeutic expression programs that:

• Activate only in defined cell types or biological states

• Respond dynamically to externally administered, clinically approved compounds

• Provide tunable control throughout development and clinical use