HIGH PERFORMANCE IVT OPTIMIZATION
Custom engineered enzymes tailored to optimize mRNA purity and process yields
GeneFab's mRNA platform is built on constant innovation. We continuously iterate and refine our processes, from sequence design and optimization to LNP formulation. This is accomplished through rigorous testing, data-driven analysis, and a dedicated team of scientists passionate about pushing the boundaries of mRNA technology, resulting in advancements in performance and reliability.
As an example of our dedication towards developing robust platform processes, we have developed engineered T7 polymerases designed to further optimize our IVT processes.
Engineered T7 Polymerase to Reduce dsRNA
The presence of double-stranded RNA (dsRNA) is a major concern in in vitro transcription (IVT), impacting the quality, efficacy, and safety of mRNA-based products. GeneFab has addressed this challenge head-on, implementing an engineered T7 polymerase in our platform mRNA-LNP process. This results in a dramatic reduction of dsRNA contamination—by over an order of magnitude.
GeneFab Engineered T7 reduces dsRNA
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X-Ray Irradiation
