Viral Vector Platforms

The engine behind
in vivo therapy.

Engineered viral vector manufacturing — the same platform fuels ex-vivo cell therapy and in-vivo gene therapy programs. Adherent and suspension, research scale through GMP, all under one roof.

Scale, tuned to your stage.

Scale matrix

From the first IND-enabling lot to commercial supply — adherent for proven processes, suspension for scalable economics. We engage at any scale and grow with you.

Platform
Description
Scale
Typical use
Adherent
Established adherent lentiviral vector platforms. Multi-tray and fixed-bed bioreactors — proven processes, fast to deploy, low-risk for early programs.
2 L — 20 L
IND-enabling, Phase I cell therapy programs
Suspension — IND-enabling
Suspension-cell-line platforms for early scale-up. Transient transfection or stable producer lines, multiple envelope options.
1.5 L — 5 L
Process development, IND lots, Phase I
Suspension — GMP
Commercial-ready suspension manufacturing in cGMP. Stable producer cell lines unlock economics for late-clinical and commercial programs.
50 L — 200 L
Late clinical, BLA-supporting, commercial

Targeting and control, built in.

What we manufacture

The full viral vector toolbox — chosen to fit your construct, your target cell, and your indication.

Lentivirus

Lentiviral vector (LVV).

Third-generation, self-inactivating lentivirus for stable integration in dividing and non-dividing cells. The standard for modern CAR-T, NK, and Treg programs.

Cell-specific promoters

Targeted expression.

Proprietary engineered promoters that drive expression only in the cells that need it — silent everywhere else. Critical for in-vivo dosing safety profiles.

Molecular switches

Molecular switches.

Engineered control elements — kill switches, regulated transgene expression, and ligand-inducible systems — built into the construct to give you on/off control over the therapy after dosing.

From construct to cleanroom.

Why this lives at GeneFab

We do viral vector as one continuous program with construct design, process development, analytical methods, GMP manufacturing, and QC release — all in the same building, with the same team.

Upstream
Construct & cell line

Vector design, payload engineering, producer cell line generation in our SynBio center.

Process
PD & analytical dev

Upstream & downstream process development, method qualification — built for tech transfer success.

cGMP
Manufacturing

Adherent or suspension GMP campaigns in seven Grade B cleanrooms — FDA & EU standards.

Release
QC & release

In-house qualified analytics — RCR/RCL, titer, identity, potency. No outsourced wait.

More capabilities.

The full set of capabilities that make up our integrated CDMO platform.